Aankhen is based on a successful Gujerati play called Andhala Pato (roughly translated to Blind Man's Buff). The movie adaptation is a big budget affair, which has Amitabh Bachchan playing a successful and disciplined bank manager who prides himself on his excellent reputation and the respect he commands from customers. Basically an honest man, his main fault lies within his bad temper. He is so passionate about his work that he tends to be a little heavy handed towards his employees, failing to tolerate any form of indiscipline or injustice.

Things get a little out of hand when he spots one of his workers cheating a customer in the bank. His temper gets the better of him and he actually raises his hand to the employee. Once the owners of the bank find out about the incident they quickly form a committee and decide to decide to sack Amitabh.

With his good name ruined, Amitabh vows revenge against the bank. He decides that he must think of a plan that will hit the bank where it hurts the most - in its safe where all the money is kept. Therefore, he gets together a team of three blind men (Akshay, Arjun and Paresh Rawal) who will help him obtain his vengeance and make a heap of money at the same time!

Paresh Rawal is like the leader of the three men and provides some comical relief in the movie. Arjun Rampal is the cool and collected third member of the trio.

Sushmita Sen plays a teacher who is forced by the thieves to use her professional skills to help their plan. Since the three men are apparently blind, her role in the scheme is obviously very important. Meanwhile Aditya Pancholi plays a cop who is on the trail of the villains.